Phospholipids conjugated to monomethoxy
polyethyleneglycol (PEG) have been around
since 1984 by coupling carboxy-PEG and
purified soy phosphatidylethanolamine
(PE). Since then the linkage between PEG
and PE has been modified to include esters
and carbamate derivatives.
The technology of liposomeology continues
to be a delivery vehicle for targeting drugs
to a specific biologic site.
Liposome research has made great strides
toward achieving this goal by the
attachment of actives to functionalized
Our research staff continues to develop
new PEG-lipid derivatives and other
biologically compatible polymeric
We have been supplying high purity bases
for over a decade. During that time, we
have worked closely with professionals and
partners through the developmental
Today we supply numerous compounding
bases and both in-office and retail products
that use lipids.
We welcome the opportunity to work with
you. Our team of chemists and
biophysicists can work with you with
technical information. We know the physical
and chemical properties of our products.
Liposomes are lipid vesicles. They are
formed when thin lipid films are hydrated
and stacks of liquid crystalline bilayers
become fluid and swell. The hydrated lipid
sheets detach during agitation and
self-close to form large multilamellar
vesicles. These vesicles prevent interaction
of water with the hydrocarbon core of the
bilayer at the edges. Once these particles
have formed, the size of the particles can
be reduced through various methods.
Properties of lipid formulations can vary
depending on the composition--cationic,
anionic, neutral lipid species. The general
procedure is to prepare the lipid for
hydration, hydration with agitation, and
sizing to a homogeneous distribution of
When preparing liposomes with mixed lipid
composition, the lipids must first be
dissolved and mixed in an organic solvent
to assure a homogeneous mixture of lipids.
The production involves a
temperature-controlled, high shear mixing
system to achieve the liposomes of the
Lipids and liposomes are used extensively
in many formulations for over two decades.
The most common use is a liposomal
formulation of vitamins A, C and E. The next
wave will be the orally ingested liposomes
which show an effect on the skin, hair and
Liposomes are uniquely suited for delivery
of actives because of their ability to deliver
water-soluble compounds in the same
particle as water-insoluble compounds.
Topical formulations of liposomal
compounds remain popular. Lipophilic
compounds such as cholesterol and
ceramides, which have been used topically
for many years because they are lipids
found in normal skin tissue, are easily
incorporated into liposomes.
We are now able to supply you with more
sophisticated compounds into liposomes.
THE ULTIMATE COMPOUNDING BASES (TM)
MANY PHYSICAL PROPERTIES AND FEATURES IN THE PRODUCTS DESCRIBED HEREIN ARE PROTECTED
BY PROPRIETARY TECHNOLOGIES AND PATENTS IN THE UNITED STATES AND OTHER COUNTRIES.
© 2010 BIOSELECT INNOVATIONS. ALL RIGHTS RESERVED.
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